PDRN (Polydeoxyribonucleotide), commonly known as Salmon DNA, is a regenerative ingredient derived from purified fragments of salmon DNA. These DNA fragments are approximately 95% structurally similar to human DNA, making them highly biocompatible with the skin. In Korean skin therapy, PDRN is often referred to as "the healer" for its ability to support the skin's natural repair processes. It helps promote skin regeneration, strengthen the skin barrier, boost collagen production, improve hydration, and enhance overall skin health.

PDRN (Salmon DNA) works by supporting your skin's natural healing response. Once delivered into the skin, it signals repair pathways, encourages collagen-producing fibroblasts, strengthens the skin barrier, improves hydration, and helps reduce inflammation. The purified DNA fragments also provide building blocks that support healthy cell repair, resulting in smoother, firmer, and more radiant skin.

Topical Salmon DNA (Spicules + Exosomes)

• Pain level:2–4/10 for most clients.

• Clients commonly describe it as:

  • A mild prickling or tingling sensation.

  • Tiny "micro-needles" or a light fiberglass feeling.

  • The sensation is usually most noticeable during application and for a few hours afterward.

• Areas like the forehead and around the nose may feel slightly more sensitive.

• There is typically minimal redness and little to no downtime compared to microneedling.

Microneedling with PDRN

• Pain level:3–6/10 with a numbing cream.

• Pain level:6–8/10 without numbing cream.

• Clients often describe it as:

  • Light scratching or vibration.

  • More noticeable over the forehead, upper lip, and bony areas.

  • Most people tolerate it well, especially after topical anesthetic.

• Redness is expected for 24–48 hours, and the skin may feel warm or tight afterward.

Salmon dna topically has little to no downtime. When combined with microneedling, expect 1-2 days of mild redness. Salmon DNA actually reduces downtime as it supports accelerated healing.

Topical Salmon DNA (Spicules + Exosomes)

• Initial glow: Immediately to a few days after treatment.

• Recommended series: 3–6 treatments, spaced 2–4 weeks apart.

• Maintenance: Every 4–8 weeks, depending on your skin goals.

Microneedling with PDRN

• Initial improvement: Within 1–2 weeks, with continued improvement over several weeks as collagen production increases.

• Recommended series: 3–6 treatments, spaced 4–6 weeks apart.

• Maintenance: Every 3–6 months to maintain results.

Topical Salmon DNA (Spicules + Exosomes)

• No needles

• Little to no downtime

• Best for hydration, glow, barrier repair, and preventative aging

• Great for sensitive skin and maintenance

Microneedling with PDRN

• Deeper delivery into the dermis

• 24–72 hours of downtime

• Best for collagen remodeling, acne scars, wrinkles, skin laxity, enlarged pores, and texture correction

• Ideal for clients seeking more transformative results

Topical Salmon DNA (Spicules + Exosomes)
For the first 24 hours, keep your skincare routine simple and focus on hydration. Use a gentle cleanser, hydrating serum, moisturizer, and broad-spectrum SPF 30+ daily. Avoid exfoliants, retinoids, acids, and other active ingredients for 3–5 days or until your skin feels fully comfortable. You may experience a mild prickly sensation or slight dryness, which is a normal part of the treatment. Avoid excessive heat, saunas, hot tubs, and prolonged sun exposure for 24 hours.

Microneedling with PDRN
Your skin will be in an active healing phase after treatment. For the first 24 hours, avoid washing your face unless otherwise instructed, do not wear makeup, and avoid touching the treated area unnecessarily. Use only the recommended post-treatment products, keep the skin well hydrated, and apply broad-spectrum SPF 30+ daily. Avoid retinoids, exfoliating acids, vitamin C, and other active ingredients for 5–7 days. Refrain from strenuous exercise, swimming, saunas, hot tubs, and direct sun exposure for 24–48 hours while the skin heals.